Understanding Diseases in Human Body through Knockout Genes – Part 2

Gene knockout (credit to YouTube)

You may read Part 1:

- Understanding Diseases in Human Body through Knockout Genes – Part 1

The knockout will result in disrupt of targeted gene.

Since mouse is closely related to humans, thus, it is favorite animal for knockout experiments.

Especially with regard to genetic questions that relate to human physiology or behaviors.

At Figure above (top of this article), we can see how to target gene.

The introduce specific gene modification in mice by the use of embryonic stem (ES) cell, then produced knockout animal (mice).

As described by Hansson (2007) that knockout have become absolutely important in medical research.

Through targeting (removing) a specific gene, we can find out what happens once it is gone.

Little plant in the early autumn

It is lead to new understanding of normal development and disease processes, then identified new avenues for medical therapy.

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References

Hansson, GK. 2007. ADVANCED INFORMATION. Gene modification in mice.

"The Nobel Prize in Physiology or Medicine 2007".

NIH (National Human Genome Research Institute). 2015. Knockout Mice.